Loss of TRMT10A led to a decrease in the levels of initiator methionine tRNA (tRNA iMet) and a specific glutamine tRNA (tRNA Gln). This reduction weakened the initiation of protein synthesis for ...

For example, the glutamine-linked tRNA (Gln-tRNA Gln) in such species is instead produced via a two-step process, a synthetic pathway that is initiated by glutamyl-tRNA synthetase (GluRS), the enzyme ...

A groundbreaking study has shed light on the critical role of a tRNA methylation enzyme, TRMT10A, in supporting brain function. The findings reveal how the absence of TRMT10A leads to a reduction ...

Loss of TRMT10A led to a decrease in the levels of initiator methionine tRNA (tRNA iMet) and a specific glutamine tRNA (tRNA Gln). This reduction weakened the initiation of protein synthesis for ...

In addition, we found that the tRNA-Leu2 rearrangement occurred in the LTPF gene cluster in the mitochondrial genome of the F. multistriata, resulting in a new arrangement (T-PL-F). There was a tandem ...

Measuring the tRNA world Researchers have developed a method to quantify transfer RNAs Date: February 26, 2021 Source: Max-Planck-Gesellschaft Summary: Transfer RNAs (tRNAs) deliver specific amino ...

Flagship Pioneering-founded Alltrna is developing tRNA therapies to address genetic diseases driven by truncated versions of proteins. By addressing an aberrant genetic instruction underpinning ...

Alltrna, the preclinical Flagship Pioneering-backed biotech trying to turn transfer RNA (tRNA) into drugs, is slimming down as it works toward the clinic. | Alltrna, the preclinical Flagship ...

Alltrna’s thesis is that one tRNA could be used to treat “thousands of diseases,” as Lovisa Afzelius, an origination partner at Flagship and co-founding CEO of Alltrna, told TechCrunch.

HC Bioscience is shutting down after conducting preclinical models for a transfer RNA (tRNA) asset designed to treat hemophilia A. | The Cambridge, Massachusetts-based biotech is closing ...