Pre-tRNA is converted into mature tRNA, which has a complex 3D structure, through a series of steps, including the excision of an intron by specific endonucleases. In humans, this is catalyzed by the ...

Journal reference: Shen, T., Hu, Z., Sun, S. et al. Accurate RNA 3D structure prediction using a language model-based deep learning approach.

Structural biology: Molecular scissors caught in the act Structure of an enzyme crucial for tRNA maturation sheds light on cause of neurodegenerative disorders Date: July 13, 2023 Source: Goethe ...

Now, researchers from Kyushu University have revealed that the smallest known protein-based tRNA-processing enzyme, called HARP, forms a star-shaped complex of 12 protein molecules, making it ...