eLife7h
Single-cell sequencing provides clues about the developmental genetic basis of evolutionary adaptations in syngnathid fishes
This study provides a valuable new resource to investigate the molecular basis of the particular features characterizing the pipefish embryo. The authors found both unique and shared gene expression ...
eLife21h
Biophysically inspired mean-field model of neuronal populations driven by ion exchange mechanisms
Hence, researchers often simulate the brain as a network of coupled neural masses, each described by a mean-field model. These models capture the essential features of neuronal populations while ...
eLife21h
Mapping the topographic organization of the human zona incerta using diffusion MRI
The zona incerta (ZI) is a deep brain region originally described by Auguste Forel as an “immensely confusing area about which nothing can be said.” Despite the elusive nature of this structure, ...
eLife21h
Dissecting infant leukemia developmental origins with a hemogenic gastruloid model
This valuable study presents a mouse gastruloid model that can be used to generate hematopoietic progenitors as well as leukemic cells. However, in its current form, the manuscript is inadequate ...
eLife21h
Variations and predictability of epistasis on an intragenic fitness landscape
This paper addresses the important question of quantifying epistasis patterns, which affect the predictability of evolution, by reanalyzing a recently published combinatorial deep mutational scan ...
eLife21h
Blood pressure variability compromises vascular function in middle-aged mice
This is an important study providing convincing evidence that increased blood pressure variability impairs myogenic tone and diminishes baroreceptor reflex. The study also provides evidence that blood ...
eLife3d
Synchronous processing of temporal information across the hippocampus, striatum, and orbitofrontal cortex
This study examined the important question of how neurons code temporal information across the hippocampus, dorsal striatum, and orbitofrontal cortex. Using a behavioral task in the rat that requires ...
eLife3d
Molecular Feature-Based Classification of Retroperitoneal Liposarcoma: A Prospective Cohort Study
Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, State Key Laboratory for Digestive Health, National Clinical Research Center for Digestive Disease, Beijing ...
eLife4d
Early Diagnosis and Prognostic Prediction of Colorectal Cancer through Plasma Methylation Regions
The methylation of plasma cell-free DNA (cfDNA) has emerged as a valuable diagnostic and prognostic biomarker in various cancers including colorectal cancer (CRC). Currently, there are no biomarkers ...
eLife5d
Disentangling acute motor deficits and adaptive responses evoked by the loss of cerebellar output
Cerebellar patients exhibit various motor impairments, but the sequence of primary and compensatory processes leading to these deficits remains unclear. To investigate this, we reversibly blocked ...
eLife4d
Volume electron microscopy reveals unique laminar synaptic characteristics in the human entorhinal cortex
The entorhinal cortex (EC) plays a pivotal role in memory function and spatial navigation, connecting the hippocampus with the neocortex. The EC integrates a wide range of cortical and subcortical ...
eLife5d
Special Issue: Reproductive health
The articles in this special issue highlight the diversity and complexity of research into reproductive health, including the need for a better understanding of the fundamental biology of reproduction ...