When AKT is inhibited, malignant cells lose their ... Functionally, EXT is very similar in AKT2 and PKA even though the sequences are only 17% identical over its full length and the conformations ...

PKA holoenzyme is a heterotetramer containing ... leptin itself might be capable of affecting cAMP by acting through the Akt pathway to activate PDE3 and cause a decrease in cAMP 42.

Researchers have discovered additional mechanisms of "Akt" activation and suggest a component of that activation mechanism -- inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKBKE ...