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An international research team led by Osaka University has identified a new mechanism crucial for the initiation of autophagy, a self-degradation process cells use to eliminate unneeded or damaged ...
Dr Marla Lipsyc-Sharf discusses how to best manage the challenging side effects associated with PIK3CA and mTOR Inhibitors to optimize patient care.
The lysosome degrades and recycles macromolecules, signals to the cytosol and nucleus, and is implicated in many diseases. Here, we describe a method for the rapid isolation of mammalian lysosomes and ...
Tongguang Wang, Marie Medynets, Kory R. Johnson, Tara T. Doucet-O’Hare, Brianna DiSanza, Wenxue Li, Yadi Xu, Anna Bagnell, Richa Tyagi, Kevon Sampson, Nasir Malik, Joseph Steiner, Alina Hadegan, ...
To manipulate the activity of mTOR at will, the CNIO team focused not on mTOR itself, but on the protein that should send the signal indicating the amount of nutrients available in the cell. The ...
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