P-S6S240 plays a role in the PI3K/mTOR cell-signaling pathway ... The PDX model that did not respond was negative for the activated S6 protein, while all responding models were positive for ...

Interestingly, the mTORC1 downstream effector phospho-S6 was active under resting conditions. Due to the frequent activation of mTOR in these cells, we decided to analyze the effect of the dual PI3K ...

Soon after rapamycin, the first mTOR inhibitor, emerged in 1990s as a potential treatment against unwanted cell proliferation, many cancer experts had hoped emerging drugs targeting mTOR would ...

On exploring the molecular mechanisms underlying this effect, the researchers found that NMJ regeneration following BTX treatment was mediated by translation signaling via the mTOR/S6 kinase ...

Overactive mTOR Plays a Key Role in Aging and Alzheimer’s Disease. Simufilam Suppresses Overactive mTOR, Suggesting a Beneficial Drug Effect. Research is Published in Frontiers in Aging ...

Resistance to endocrine therapy in breast cancer is associated with activation of the mammalian target of rapamycin (mTOR) intracellular signaling pathway. In early studies, the mTOR inhibitor ...

The results suggested that mechanistic target of rapamycin (mTOR) inhibition is a potential therapeutic avenue for sarcoidosis, which the authors said should be explored in larger clinical trials.

P-S6S240 plays a role in the PI3K/mTOR cell-signaling pathway ... The PDX model that did not respond was negative for the activated S6 protein, while all responding models were positive for ...