In mRNA, as well as nucleoside modifications that are associated with the 5′-cap (ref. 4), six nucleosides with base modifications have been discovered so far: N6 -methyladenosine (m 6 A) (refs ...

Researchers discovered that a modification to the synthetic mRNA used in therapeutics can cause the cell’s machinery to misread its instructions, leading to unintended immune responses ...

Duke researchers published a breakthrough in understanding m6A through the development of a genetically encoded sensor for the most abundant internal mRNA modification. These mRNA modifications ...

The researchers identified that bases with a chemical modification called N1-methylpseudouridine - which are currently contained in mRNA therapies - are responsible for the 'slips' along the mRNA ...

m6A mRNA modification potentiates Th17 functions to inflame autoimmunity Peer-Reviewed Publication Science China Press ...

The m 6 A modification affects the entire life cycle of mRNA, including pre-mRNA splicing, 3′-end processing, nuclear export, translation, stability, and decay.

In mice, the drug—an mRNA with a dual-branched cap and other modifications—caused cells to produce eight times more protein than regular mRNA.

CMTr cap-adjacent 2′-O-ribose mRNA methyltransferases are required for reward learning and mRNA localization to synapses. Nature Communications, 2022; 13 (1) DOI: 10.1038/s41467-022-28549-5 ...

"We're also studying the possibility of using Cap2 modifications to improve mRNA-based therapeutics, including vaccines, by reducing their inflammatory effects in cells," Dr. Jaffrey said.

Repurposing RNA sequencing for discovery of RNA modifications in clinical cohorts. Science Advances, 2021; 7 (32): eabd2605 DOI: 10.1126/sciadv.abd2605 ...

Nobel Prize-winning mRNA technology, which saved millions of lives during the COVID-19 pandemic through vaccines, is now ...