A new study in Nature identifies a long-sought cytoplasmic 'sensor' that is responsible, at least in part, for interferon responses induced by double-stranded DNA. How do cells detect non-self ...
cGAMP is generated from GTP and ATP by cytoplasmic dsDNA sensor cGAS. Our group combined structural, chemical (lab of collaborator Roger Jones), biochemical (lab of collaborator Thomas Tuschl) and ...
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Complex interactions between nucleic acid sensors and enzymes in immune cells explainedThe intracellular role of ADA2 in TLR9 activation was investigated, as TLR9 is a key receptor activated by dsDNA in response to infections and autoimmune diseases. The study found that ADA2 ...
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