The buildup of uric acid in your joints can lead to swollen growths under your skin called tophi. If left untreated, tophi can lead to loss of motion in your joints and other complications.

In the final stage, large crystals called tophi can cause joint damage and structural changes. Read on to learn more about the four stages of gout. Gout progresses through four stages. With proper ...

Tophi are firm, painless yellow lesions that form in and around the joints in people with advanced gout. They have a uric acid (monosodium urate) core, and the skin that covers them can become ...

People with tophaceous gout can get tophi, which are hard uric acid deposits that form beneath the skin. Tophi look like chalky lumps under the skin. They can be found on or near the elbow ...

The present study quantifies the impact of the presence of tophi and frequency of acute gout attacks on health-related quality of life (HRQOL), productivity, and healthcare resource utilization.

If crystals build up under the skin, and form small white or yellow lumps known as tophi - caused by tophaceous gout - it can be a sign the condition is serious. NHS Choices said: “Tophi are ...

One study retrospectively analyzed data from two 6-month, randomized clinical trials that evaluated Krystexxa in patients with and without clinically apparent tophi. Both patient groups ...

From there, van Leeuwenhoek went on to be the first person to identify gouty tophi, among many other discoveries. His accomplishments earned him induction into the Dutch Royal Society in 1680.

Patients with confirmed tophi and more frequent acute gout attacks had lower HRQOL, and the association between HRQOL, tophi and flares remained significant even after accounting for covariates.