To this end, the research team set out to silence WT1 gene expression in malignant glioma cells and observe the effects of this silencing on other genes in these cells. The researchers did this by ...

Thus, different WT1 isoforms have distinct effects in this cell line, suggesting that depending on the ratio of WT1 isoform expression in mammary epithelial cells, WT1 could function to either ...

WT1 performs this function without significantly affecting the expression of genes crucial for SAC/MCC regulation. We also found that depletion of MAD2 by siRNA does not influence transcription of ...

We previously identified mutations in the zinc-finger domains of the WT1 gene in 8% of pediatric patients with AML. 6 Although these mutations are predicted to lead to loss of function of WT1, we ...

Of 201 patients with WT in the cohort, eight patients were carriers of mutations in the WT1 gene. Six of the eight mutations were protein-truncating nonsense mutations. None of 56 patients with ...

The WT1 gene fulfills a central role in the development of a healthy, proper functioning kidney. Mutations in WT1 lead to impairments in kidney development and cause Wilms tumors, a pediatric ...

New perspectives on Wt1 gene functions Endothelial cells form the inner cell layer of blood vessels and have a wide range of essential functions in the development of tissues and organs such as ...

New perspectives on Wt1 gene functions Endothelial cells form the inner cell layer of blood vessels and have a wide range of essential functions in the development of tissues and organs such as ...

The FDA granted orphan drug designation to the WT1 cancer vaccine for the treatment of malignant pleural mesothelioma.The FDA based the designation on results from a randomized, double blind ...

Gene WT1 impacts women's fertility, study finds Date: March 28, 2017 Source: Leibniz Institute on Aging – Fritz Lipmann Institute (FLI) Summary: It has been estimated that more than 80 million ...

The deletion of the Wt1 gene during the early stages of the embryonic reproductive organ formation leads to differences in sex development in adult mice, according to an article published in the ...

To date, it has been hard to assess the functions of the WT1 transcription factor -- coded by the mentioned gene- during the early differentiation of the gonad and its impact on adult sex development.