To date, it has been hard to assess the functions of the WT1 transcription factor -- coded by the mentioned gene- during the early differentiation of the gonad and its impact on adult sex development.

New perspectives on Wt1 gene functions Endothelial cells form the inner cell layer of blood vessels and have a wide range of essential functions in the development of tissues and organs such as ...

The −KTS splice variant of WT1 is essential for ovarian determination in mice. Science, 2023; 382 (6670): 600 DOI: 10.1126/science.add8831 ...

image: this study revealed the LSD1-induced gene expression profiles that promote FSH responsiveness in GCs by regulating autophagy and repressing Wt1 expression during antral follicles formation ...

Wilms' tumor gene WT1 is expressed in various kinds of cancers including pancreatic cancer. In pilot clinical trials of DC vaccination loaded with WT1 peptides for patients with advanced pancreatic ...