In lab studies, the orally active drug has been shown to degrade the VAV1 protein expressed in T- and B- cells. VAV1 is thought to be a signalling protein involved in the production of pro ...

Investigators sought to understand the safety and tolerability of MRT-6160, along with its ability to degrade a nucleotide exchange factor, VAV1. VAV1 plays a crucial role in several immune ...

MRT-6160 degrades a protein called VAV1. "Overall, we see this favorable collaboration agreement as additional robust validation of Monte Rosa's (platform) as well as acknowledgement of the ...