ASCO: Sarclisa is first anti-CD38 to significantly improve progression-free survival in combination with VRd for newly diagnosed transplant-ineligible multiple myeloma in phase 3 Sarclisa, in ...

Patients who received daratumumab plus VRd (D-VRd) had an estimated four-year PFS rate of 84.3% compared with 67.7% among those receiving VRd alone, a difference of about 17%.

Surbhi Sidana, MD, MBBS, shares how the addition of an anti-CD38 antibody to the VRd regimen significantly improves progression-free survival for patients with transplant-ineligible multiple myeloma.

A median PFS was not reached for daratumumab plus VRd, compared with 52.6 months for the VRd group, while estimated 54-month PFS rates were 68.1% vs 49.5%, respectively.

Digging deeper into the data, patients on Darzalex-VRd achieved an overall MRD negativity rate of 60.9% at around 59 months versus 39.4% in the cohort that received the VRd regimen alone.