The in vivo phenotype of the index patient was characterized by investigating exercise capacity and cardiopulmonary responses to acute hypoxia (end-tidal partial pressure of oxygen, 50 mm Hg).

Many important findings developed, including the belief that HIF (hypoxia-inducible factor ... Despite the gains, many questions remain. VHL is a cancer syndrome characterized by highly vascularized ...

A normal VHL gene produces VHL protein, which interacts with hypoxia-inducible factor (HIF) protein when oxygen levels are normal, but uncouples from HIF when oxygen levels fall, thereby functioning ...

Specifically, the disorder affects the VHL gene on chromosome 3. There’s a protein in your body called hypoxia-inducible factor (HIF), which helps your body manage how oxygen is used by cells.

(UroToday.com) The 2025 American Society of Clinical Oncology (ASCO) Annual Meeting held in Chicago, IL, was host to a State ...

VHL is caused by a single defect in a gene responsible ... The drug is an antineoplastic agent that acts by blocking the activity of hypoxia-inducible factor 2 alpha (HIF-2α), which regulates ...

This leads to the hypothesis that the severity of the familial or sporadic disease may be dictated by additional genetic defects in the hypoxia-HIF-VHL or parallel pathways. These promoting defects ...

WELIREG is a first-in-class oral hypoxia-inducible factor-2 alpha (HIF ... systemic therapy to adult patients in China with certain VHL disease-associated tumors who, to date, have not had access ...