an oral hypoxia-inducible factor-2 alpha (HIF-2α) inhibitor, as a single agent for the treatment of adults with von ...

and that the nonhydroxylated HIF-α is protected against VHL-mediated degradation. Under hypoxia conditions, HIF-α therefore becomes available to dimerize with its partner, the aryl hydrocarbon ...

Scientists knew that in low oxygen situations, or hypoxia, cells trigger a cascade ... who had spent time researching von Hippel-Lindau (VHL) disease, a rare genetic disorder that increases ...

VHL is a negative regulator of the Hypoxia Inducible Factor (HIF) signalling pathway, which is vital for development and survival of many tumours. However, this is not the only function of VHL and ...