The researchers show that ephrin-B2 regulates the proper spatial activation of VEGFR-2 endocytosis and signaling at the tip cell filopodia. In vitro, endothelial cells from Efnb2-knockout and ...

PharmAbcine's pipeline is spearheaded by olinvacimab, an antibody targeting vascular endothelial growth factor receptor 2 (VEGFR-2; also known as KDR). The VEGF/VEGFR-2 pathways are central to ...