The cardiac thin filament governs contraction by sensing intracellular calcium levels, with conformational changes occurring at a threshold of pCa 6, enabling myosin-actin cross-bridge cycling and ...

Each day the average human heart beats 100,000 times and pumps about 2,000 gallons of blood. It's a process that is critical to life, and yet it often goes awry for unknown reasons.

CK-2127107, a novel skeletal muscle activator arising from Cytokinetics' skeletal muscle contractility program, slows the rate of calcium release from the regulatory troponin complex of fast ...