If left untreated, tophi can lead to loss of motion in your joints and other complications. A tophus (plural: tophi) happens when crystals of the compound known as sodium urate monohydrate ...

Pegloticase quickly resolved tophi among patients with gout who responded to the treatment, according to data published in Arthritis Research & Therapy. “Pegloticase is a recombinant mammalian ...

In a phase 2 global trial, 42 patients with gout and subcutaneous tophi were randomly assigned ... group had complete resolution of at least 1 tophus compared with 1 patient (8%) in the AR882 ...

On blinded ultrasound evaluations, the median diameter of the first MTP tophus declined significantly more with tight control than with conventional management (-4.65 mm vs -0.30 mm; P ...

In advanced disease, the MSU crystals are embedded in an amorphous whitish matrix referred to as a tophus. These tophi are localized macroscopic lesions that can be clinically silent for a long ...

001). Of patients with tophi at baseline, 53.8% in the MTX group vs 31.0% in the placebo group experienced resolution of 1 or greater tophus at month 12 (P =.048). Rates of tophus resolution ...

Among patients with validated tophi at baseline, 54% of patients treated with Krystexxa plus methotrexate achieved a complete response at month 12, defined as 100% resolution of at least 1 tophus ...

If crystals build up under the skin, and form small white or yellow lumps known as tophi - caused by tophaceous gout - it can be a sign the condition is serious. NHS Choices said: “Tophi are ...

My husband suffers from gout and has had tophi on both elbows for a few years now. Can they be surgically removed? My husband has had 3 conflicting diagnoses with regards to removing the tophi from ...