The buildup of uric acid in your joints can lead to swollen growths under your skin called tophi. If left untreated, tophi can lead to loss of motion in your joints and other complications.

The present study quantifies the impact of the presence of tophi and frequency of acute gout attacks on health-related quality of life (HRQOL), productivity, and healthcare resource utilization.

Pegloticase quickly resolved tophi among patients with gout who responded to the treatment, according to data published in Arthritis Research & Therapy. “Pegloticase is a recombinant mammalian ...

Bone erosion in patients with gout and tophi was associated with tophi duration, drinking history, ulceration, and serum creatinine levels. Bone erosion in patients with gout and tophi was ...

Diagnosis CT showed no internal derangement, but revealed extensive intra-articular and extra-articular amorphous soft tissue calcifications, compatible with gouty tophi. Management The patient ...

Credit: Shutterstock. The investigational drug AR882 appeared more effective and safer than allopurinol monotherapy in a phase 2 trial. A novel selective URAT1 inhibitor, AR882, further reduces ...

My husband suffers from gout and has had tophi on both elbows for a few years now. Can they be surgically removed? My husband has had 3 conflicting diagnoses with regards to removing the tophi from ...

The primary endpoint is reduction of sUA by month six. Secondary endpoints include a reduction in flare and tophi over time. The trial is expected to be fully enrolled in 2025 and completed by the ...

Patients with confirmed tophi and more frequent acute gout attacks had lower HRQOL, and the association between HRQOL, tophi and flares remained significant even after accounting for covariates.