Tophi are a collection of uric acid crystals ... The first gout attack typically affects the big toe. However, the hands are ...

The uric acid crystallizes, causing hardened clusters of uric acid crystals in a joint known as tophi. The big toe is most commonly affected, but other toes or fingers can be affected as well.

She also had numerous small subcutaneous tophi in her hands. The patient was intolerant to allopurinol and had mild renal insufficiency attributed to uric-acid nephrolithiasis and interstitial ...