Medications and their Potential to Cause Increase 'Gouty tophus' Developed by - Dr. M. Janani Priya, Pharm D Reviewed by - Dr. M. Sree Mohana Preetha, Pharm D Last Updated on Nov 16, 2023 ...

A tophus can occur when you have gout and uric acid builds up around your joints. Larger tophi need to be removed so they don’t cause long-term damage.

Complete resolution of at least one tophus at 6months was achieved by 69.6% of responders, 27.9% of nonresponders and 14.3% of those who received placebo.

The second randomized trial of therapy to intensively lower urate for patients with gout showed benefits in meeting serum urate goal, tophus size, and decreasing ultrasound sign.

The percentage of patients seeing complete resolution of at least one tophus grew markedly, to 53.8% at month 12 from 34.6% at the 6-month evaluation.

Using the Delphi process to assess the semi-quantitative scoring system for aggregate, tophus, and double contour lesions, both intra- (κ=0.74-0.80) and inter-reader reliabilities (κ=0.61-0.67 ...

For example, there are only two ICD-9 codes for chronic gout — 274.01 for the kind without tophus, and 274.02 when tophus is present. ICD-10 has dozens of codes for chronic gout.

A 23 percentage-point increase in the complete resolution of at least one tophus at Month 12 (p=0.048): among patients with tophi at baseline, 53.8% (28 of 52) in the KRYSTEXXA with methotrexate group ...

However, lesinurad combination treatment with both 200mg and 400mg did result in greater total tophus area reduction at month 12 compared to febuxostat alone (nominal p<0.05).