Membrane proteins, including TMEM16F, constitute a particularly complex field of study. To fully comprehend their structure and function, it is necessary to study them in their native environment.

To gain a better understanding of TMEM16F’s structure and function relationship, Holger Flechsig and Clemens Franz from WPI-NanoLSI, Kanazawa University, in collaboration with Vincent Torre from ...

Cryo-EM structures and functional characterization of the murine lipid scramblase TMEM16F. eLife, 2019; 8 DOI: 10.7554/eLife.44365 ...

Notably, TMEM16F functions as a Ca 2+ -activated ion channel and a Ca 2+ -activated lipid scramblase.

Our findings mark TMEM16F as a possible new target for the development of effective treatments for Parkinson’s disease.

The TMEM16 family of membrane proteins was hailed as representing the elusive calcium-activated chloride channels. However, the majority of the family members turned out to be scramblases, proteins ...

Big question However, big questions remained: ‘We wanted to know how the scramblases are regulated by calcium, and how some of them can simultaneously facilitate ion transport.’ To that end, her newly ...