Mechanism of Action of Direct Thrombin Inhibitors as Compared with Heparin 1m 0s Direct thrombin inhibitors (DTIs) are a new class of anticoagulants that bind directly to thrombin and block its ...

Direct thrombin inhibitors (DTIs) are a type of anticoagulant used to treat atrial fibrillation and other conditions that can lead to stroke. Direct thrombin inhibitors work by latching onto a ...

NEW YORK (CNNMoney.com) -- It'll take more than an ad during the Super Bowl to protect King Pharmaceuticals from the two scrappy biotechs plotting to end its near-monopoly on surgical blood clot ...

The serine protease thrombin regulates platelet aggregation, endothelial cell activation and other important responses in vascular biology. Thrombin's actions on cells raise an intriguing question.

Thrombin is a central regulator of leukocyte recruitment and inflammation at sites of vascular injury, a function thought to involve primarily endothelial PAR cleavage. Here we demonstrate the ...

3–5 Vorapaxar (SCH 530348, Merck) is an oral competitive PAR-1 antagonist that inhibits thrombin-induced platelet aggregation. In two phase 2 trials involving patients undergoing elective ...

Direct inhibition of thrombin may offer similar anticoagulant properties but also impact the underlying disease process. As we continue to gain experience and develop new DTIs, a new balance may ...

Evidence-based recommendations on thrombin injections for pseudoaneurysms. This involves injecting thrombin into the pseudoaneurysm. The aim is to form a small clot to plug the ‘hole’ in the artery.

One kind you may get after a DVT is called a direct thrombin inhibitor. There’s an enzyme in your blood called thrombin. When you’re bleeding, its job is to turn a particular protein into ...

In this procedure, thrombin (a blood-clotting agent) is injected under ultrasound guidance into the pseudoaneurysm. This causes thrombosis of the pseudoaneurysm cavity, which seals the arterial ...

Intravenous administration only. Used for the treatment of HIT (heparin induced thrombocytopenia). Monitored by aPTT - goal is 1.5 to 3.0 times above baseline. Renally cleared. Not easily reversed ...