T helper 17 (Th17) cells generate the pro-inflammatory cytokine interleukin-17 (IL17/IL17A). IL17 has been a target for a variety of therapeutic monoclonal antibodies and inhibitors to treat ...

One of the most recent and perhaps most promising developments in psoriasis research is the role of the Th17 CD4 + T cell and one of its cytokines, IL-17, in disease development, progression and ...

This activates the NFκB pathway. NFκB drives production of IL-24, which in turn suppresses the Th17 cytokine program via SOCS1 and 3.

Th17 lymphocytes produce the pro-inflammatory cytokine IL-17 which provides protection against mainly extra-cellular pathogen infections. However IL-17 release has been hardly studied in neonates.

Guselkumab targets the p19 alpha subunit of IL-23. While IL-23 promotes normal inflammatory and immune responses, the p19 and ...

One of the most recent and perhaps most promising developments in psoriasis research is the role of the Th17 CD4 + T cell and one of its cytokines, IL-17, in disease development, progression and ...