After years of playing second fiddle to amyloid as a drug target in Alzheimer's disease, there are signs of increasing interest in the development of tau protein-targeting drugs. Earlier this ...

Biogen reported that BIIB113, a small-molecule O-GlcNAcase inhibitor designed to prevent tau from transforming into a pathological form bound to its target in the brain and was safe in healthy ...

"For the first time, we have identified the gene that oversees tau function, and have a promising target for developing treatments to prevent and slow the progression of Alzheimer's disease and ...

The potential role of these truncated tau proteins in the development of AD underscores the need to target these proteins to diagnose and treat this neurodegenerative disorder. Alzheimer’s ...