Surprisingly, this function of talin is independent of integrins. These results uncover a new role for talin in regulating cadherin-mediated cell adhesion.

Talins are essential for integrin activation, focal adhesion formation and mesenchymal cell migration. The E3 ubiquitin ligase Smurf1 regulates talin head degradation and Cdk5-mediated ...

By applying the method to the cell adhesion protein talin, the researchers at the Max Planck Institute discovered the central mechanism that allows cells to feel their mechanical environment. “Talin ...

Talin binds to integrin via its "head" and connects it to the cytoskeleton, thereby acting as a part of the cellular mechano-signalling network, which affects cell adhesion, migration, but also ...