News & Views Published: 01 July 2005 A new TRP to kidney disease Thomas Gudermann Nature Genetics 37, 663–664 (2005) Cite this article ...

Increased TRPC6 activity from enhanced gene expression or gain-of-function mutations contribute to cardiac and/or renal disease. Despite evidence supporting a pathophysiological role, no orally ...

They also conducted tissue collection and histology following the termination of the experiment. The study found that blocking TRPC6 in mice with DMD doubled their lifespan and improved muscle ...

Journal reference: Lin, B.L., et al. (2022) Pharmacological TRPC6 inhibition improves survival and muscle function in mice with duchenne muscular dystrophy.

A Dual Role of Mesenchymal Stem Cell Derived Small Extracellular Vesicles on TRPC6 Protein and Mitochondria to Promote Diabetic Wound Healing Journal: ACS Nano Published: 2024-01-30 DOI: ...