ICRAFT pinpointed TNFAIP3 (A20) as a crucial gene with dual immunoregulatory effects: In tumor cells, loss of TNFAIP3 activates TNF-induced apoptosis, upregulates NF-κB signaling, and enhances ...

(i)Loss of TNFAIP3 activates TNF-induced apoptosis, upregulates NF-κB signaling, and enhances chemokine expression, promoting T cell infiltration. (ii)This makes tumor cells more vulnerable to ...