Sanofi’s development of an oral spin on Humira’s mechanism has hit a setback. | Sanofi’s development of an oral spin on ...

Rheumatoid arthritis (RA) patients in Denmark with a history of solid tumor cancers, now in remission, faced no greater ...

There are currently four monoclonal antibodies available that are directed against TNF: infliximab, adalimumab, golimumab and certolizumab. All of these agents are efficacious in RA, with clinical ...

In patients with RA, TNF inhibitor use during the 3 years after being diagnosed with early-stage lung, colorectal, or prostate cancer was not linked to decreased survival.

Worries that tumor necrosis factor (TNF) inhibitors may exacerbate or even cause lung disease in patients with rheumatoid ...

Since the validation of anti-TNF therapy for the treatment of RA, much effort has gone into making small-molecule inhibitors that lack the cost and adverse effects associated with current large ...

An increased risk of both invasive and superficial fungal infections was observed among patients who received TNF-α inhibitors for various conditions.

In fact, defective clearance of immune cells has been demonstrated in RA. In accordance with the role of TNF in inducing the release of TL1A, treatment of RA patients with an anti-TNF monoclonal ...

Neuroimmune modulation represents a promising treatment strategy that uses vagus nerve stimulation to reduce inflammation in ...

The picture that has emerged for TNF is that it plays a central role in the network of cellular and molecular events involved in RA. Because of this, TNF inhibitors are often a first choice in a ...