This recent study highlights the neuroprotective potential of TFE3, a transcription factor that plays a pivotal role in ...

TFEB and TFE3 are two key transcription factors that regulate lysosomal biogenesis. TFEB/TFE3 links autophagy and lysosomal biogenesis through the transcriptional activation of genes involved in ...

Activated p53 negatively regulates mTORC1 signaling, which is one of the major kinases responsible for the phosphorylation of TFEB and TFE3. The autophagy-lysosomal pathway is activated via the ...

Zevra Therapeutics, Inc. (NasdaqGS: ZVRA) (Zevra, or the Company), a commercial-stage company focused on providing therapies for people living with rare disease, today announces the publication of ...

The publication presents data demonstrating that arimoclomol enters the cell and increases the translocation of translation factors EB and E3 (FTEB & TFE3) from the cytosol to the nucleus ...