Levels of the surface receptor GluR1, orange, are shown in unmodified neurons, left, and in those with increased levels of Tet3, right. Disclaimer: AAAS and EurekAlert! are not responsible for the ...

To target these pathogenic macrophages, we used a synthetic small molecule that triggers protein degradation of TET3. Because the compound relies on coexpression of an enzyme that is also upregulated ...