We studied the association of TI-CH with survival and disease recurrence and evaluated the functional effect of TET2-mutant CHIP on the biologic features of lung tumors. Among patients with NSCLC ...

TET2 mutations were the strongest genetic predictor of tumor-infiltrating clonal hematopoiesis. In this study, age-associated tumor-infiltrating clonal hematopoiesis emerged as an important factor ...

The researchers also discovered that when mutations affected a gene called TET2, which is an important regulator of blood cell production, across thousands of individuals, the TET2 mutant blood ...

diagnosis hinges on flow cytometric identification of aberrant NK-cell receptor expression (e.g., restricted KIR isoforms, altered CD94/NKG2A). STAT3 and TET2 mutations are common, with unique ...