"There was sufficient justification for new trials of our current T3 preparation based on the ... who have genetic polymorphisms of deiodinase enzymes, which play a key role in the activation ...

keeping the proper ratio of T4 to T3 for humans. There are some people (about 16%) who have a different type of an enzyme called type 2 deiodinase, and those people are not well able to convert T4 ...

in the enzyme known as D2 that transforms T4 to T3. In a previous study, hypothyroid patients with this polymorphism preferred the combination therapy, which led Dr. Bianco and his team to explore ...

This enzyme converts T4 into T3, raising the level of the active form of thyroid hormone in the organ. T3 resulting from the action of D2 is transported to neuronal cells adjacent to the glials. In a ...

It may be that these patients have trouble converting T4 into the active version of the hormone, T3. This process is dependent on enzymes in the body that need certain nutrients to function.

The enzyme, called an ATPase, provides energy to run the motor needed to insert DNA into the capsid, or head, of the T4 virus, which is called a bacteriophage because it infects bacteria. The same ...