The transient receptor potential cation channel, subfamily M, member 1 (TRPM1/Melastatin-1/MLSN-1) expression has been shown to have prognostic utility in the evaluation of primary cutaneous melanoma.

Of those 12 patients originally diagnosed with thin melanoma, pathologic review led to a change in diagnosis to Spitz nevus (n = 3; Appendix Fig A1, online only), compound Clark nevus (n = 4), ...

They included 30 congenital nevi, 19 compound nevi, 40 Spitz nevi, 48 primary melanomas, ... Modern Pathology - Fatty acid synthase expression in cutaneous melanocytic neoplasms.

Among the various subtypes, Spitz melanoma is particularly difficult to diagnose and poses a significant challenge in the fields of pediatric dermatopathology and surgical pathology.

A Spitz nevus is an uncommon type of mole that is usually raised, dome-shaped, and pigmented. Anyone can have a Spitz nevus, or multiple, but they’re more common in children and people with fair ...

Investigators report on a 10-year data review of these melanocytic tumors, a unique form of mole or nevus that ranges from benign to borderline and malignant, and stumps even the most experienced.

A pediatric melanoma registry developed at St. Jude Children’s Research Hospital has helped researchers improve the classification of pediatric melanocytic tumors.The registry, called Molecular ...