Ossification of the posterior longitudinal ligament (OPLL) is a progressive spinal disease characterized by ectopic bone ...

Molecular biologists often tinker with the machinery of cells to figure out how they work. But for ancient machines like the ribosome, such tinkering isn’t straightforward, said Alexander Mankin ...

Tagging ribosomes ... how cells might change during development, in disease or in response to different experiences.” Initially the Heintz team attempted expression profiling of cells by using ...

This study provides evidence that single-cell multi-omics profiling can reveal key regulators of HIV-1 persistence and early immune dysregulation, particularly implicating KLF2 and Th17 cells as major ...

Researchers developed a technique to gain a deeper understanding of ribosome function and their cooperative behaviors.

2005). This is a major an advance over polysome profiling, which can yield information only about the total number of ribosomes bound to an mRNA. In both techniques, one lyses cells in the ...

"In this study, we combined ribosome profiling ... cleverly manipulates our cells, these discoveries will bring us closer to innovative treatments that could one day turn the tables and outsmart ...

The authors further noted, “Using single-cell, spatially resolved molecular profiling, we find that DRN neurons expressing cholecystokinin (CCK) comprise a unique neuropeptidergic subpopulation ...