The Philadelphia Citizen is recognizing CHOP doctors Alexis Thompson and Dr. Stephan Grupp with the 'Disruptors of the Year' ...
In December 2023, through the development efforts of CRISPR Therapeutics and Vertex Pharmaceuticals, their decades-long ...
The relationship of genotype to phenotype is rarely as simple as the ... The altered form of hemoglobin that causes sickle-cell anemia is inherited as a codominant trait. Specifically ...
The high cost of sickle cell gene therapies is pushing private insurers and Medicaid programs to develop new payment models.
How do mutations happen, and how do they influence the future of a species? Molecules of sickle-cell hemoglobin stick to one another, forming rigid rods. These rods cause a person's red blood ...
Children with sickle cell disease, a chronic hemolytic anemia, present with a wide variety of neurological syndromes, including ischemic and hemorrhagic stroke, transient ischemic attacks ...
This could alter an individual's phenotype. A mutation can be neutral ... body cells then they will have the genetic condition sickle cell anaemia. The sickle shaped red blood cells can block ...
"This causes a metabolic phenotype that resembles a glutamine ... L-glutamine is also used to alleviate symptoms of sickle cell disease, but how this drug works has similarly been contentious.