Using RNA sequencing databases of cancer patients, the researchers found that STAT3 and STAT5 work together to control the quantity of dendritic cells. Through transcriptional signaling, each protein ...

Mechanistically, NR2F1 directly interacts with the STAT3 promoter, resulting in its transcription. In turn, STAT3 promotes fibrosis and enhances lens epithelial cell migration and apoptosis ...

JAK/STAT signaling in a bind. a, The binding of IL-6 to its receptor (IL-6R) induces homodimerization of gp130, which leads to cross-phosphorylation and activation of the associated JAK2.STAT3 is ...