IFN-α treatment was 15 min ... Antibodies against STAT1, STAT2, STAT3, STAT5, STAT6, Jak1 and tyk2 were purchased from Santa Cruz Biochemicals (Santa Cruz, California). Antibodies against ...

New research identifies the liver protein PTPRD as a key regulator of metabolic liver disease. Reduced levels of PTPRD disrupt glucose and lipid metabolism, promote liver fat accumulation, and impair ...

JAK/STAT signaling in a bind. a, The binding of IL-6 to its receptor (IL-6R) induces homodimerization of gp130, which leads to cross-phosphorylation and activation of the associated JAK2.STAT3 is ...