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Study in mice links immune system to ADHD, neurobehavioral conditions
The finding, appearing this month in the journal Brain, Behavior, and Immunity, adds insight to an on-off switch for genes called STAT1. This gene regulator plays a pivotal role in the immune ...
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A working model of IFNγ-STAT1 signaling promoting axon regeneration in CNS and PNS. (IMAGE)
In CNS, such as retinal ganglion cells, IFNγ activates STAT1 in Ptpn2 cKO RGCs. STAT1 then upregulates neuronal cGAS expression. cGAS produces cGAMP and activate STING in neurons. In PNS ...
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Dopamine neurons’ sensitivity to immune system gene offers clues to hyperactivity and behavioral disorders
Researchers at Duke Health have uncovered a connection between an immune system gene regulator, STAT1, and hyperactive behaviors in mice. Their study, published in the journal Brain, Behavior ...