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In organoid and target selectivity experiments, DC646 effectively reversed the expression of GW4064-induced FXR target gene small heterodimer partner (Shp) in an FXR-dependent manner without ...
In organoid and target selectivity experiments, DC646 effectively reversed the expression of GW4064-induced FXR target gene small heterodimer partner (Shp) in an FXR-dependent manner without ...
Bile-acid-mediated activation of FXR-α-signalling pathways regulate the enterohepatic recycling of bile acids, protect against their accumulation in the liver and inhibit their own biosynthesis.
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