SH3 and SAM domains are protein interaction motifs that are predominantly seen in signaling molecules, adaptors, and scaffold proteins. We have identified a novel family of putative adaptor genes ...

Protein–protein interactions play critical regulatory roles in mediating signal transduction. Previous studies have identified an unconventional, small-molecule, Src signal transduction ...

MK-STYX is a novel protein included in the dual specificity mitogen-activated protein kinase phosphatase class that lacks the essential nucleophilic cysteine required for phosphatase activity.

We have identified a role for Nervous Wreck (Nwk), an F-BAR/SH3 protein, in regulating EV traffic at the Drosophila NMJ. nwk mutant animals have a reduction in EV cargoes, including Syt4, an important ...