A research team has unveiled a crucial mechanism that helps regulate DNA damage repair, with important implications for ...

Researchers from the University of Birmingham have uncovered answers that provide the detail to explain two specific DNA ...

Mechanistic studies demonstrated that upon radiation-induced DNA damage, ZNF451 rapidly accumulates at damage sites and specifically catalyzes SUMO 2 modification of RNF168. This post ...

Researchers have uncovered answers that provide the detail to explain two specific DNA repair processes that have long been in question.

The ubiquitin ligase, RNF168, promotes DNA break repair but must be regulated to prevent run-away ubiquitin signaling. Here, the authors identify a three-step post-translational cascade regulating ...