Kinsella and Evandy assessed whether blocking one of the players, called Rac1, (thereby boosting IL-22 and Bmp-4) helps improve thymic function after damage. They treated mice with an experimental ...

FSGS is characterized by an overactivation of the TRPC5-Rac1 pathway. By inhibiting the TRPC5-Rac1 pathway, GFB-887 is designed to protect podocytes, reduce proteinuria, and slow or halt disease ...