Recent structures of the Runx1–CBFβ heterodimer bound to DNA brings to six the number of characterized eukaryotic transcription factor families that use an immunoglobulin (Ig) fold to bind to DNA.

In terms of specific mutations, 6 patients had ASXL1, 5 had RUNX1 and 3 had TP53. The median age was 71 (range 35-89 years). The median number of prior failed therapy was 1 (range 1-6).