Here, mTOR phosphorylation was found to decrease, and as well as the downstream targets of mTOR 4EBP and RPS6, the phosphorylation status also decreased dramatically.

The lysosome degrades and recycles macromolecules, signals to the cytosol and nucleus, and is implicated in many diseases. Here, we describe a method for the rapid isolation of mammalian lysosomes and ...

Dr Marla Lipsyc-Sharf discusses how to best manage the challenging side effects associated with PIK3CA and mTOR Inhibitors to optimize patient care.

To manipulate the activity of mTOR at will, the CNIO team focused not on mTOR itself, but on the protein that should send the signal indicating the amount of nutrients available in the cell. The ...