RCC can be histologically ... a very high frequency of biallelic VHL inactivation caused by allelic deletion or loss of heterozygosity (LOH) on chromosome 3p (>90%) 4 along with gene mutation ...

with the loss of the 3p chromosome as well as a frequent loss of chromosome 9p. Clear cell RCC is associated with von Hippel-Lindau (VHL) disease. It is the evaluation of this genetic ...

Patients with BAP1-mutated renal cell carcinoma who were treated with Lynparza obtained responses with favorable side effect profiles. Patients with renal cell carcinoma (RCC) whose tumors had gene ...

VHL also can cause cancerous tumors in the kidney or pancreas. RCC affects approximately 40% of people with VHL disease and is one of the most common causes of disease-related death in people with ...

Most patients (74.2%) were men, and the median age at diagnosis of renal neoplasia was 63 years; most had clear cell RCC. Immunohistochemical analysis revealed BAP1 loss in clear cell RCC tumor ...

by RCC subtype (papillary RCC [pRCC] and chromophobe RCC [chRCC]), and by gene mutations (VHL, BAP1, SETD2, and ARID1A). The five-year diagnosed prevalent cases of RCC are also included in the report.

The loss of BAP1 protein expression is associated with an increased risk for death in patients with low-risk clear-cell renal cell carcinoma, according to study results. BAP1 mutations — which ...

In Patients With Renal Cell Carcinoma Receiving Everolimus, Acute Kidney Injury is Common Belzutifan is a potent and selective inhibitor of HIF-2α. The Food and Drug Administration (FDA) has ...