The team's work reveals specific functions of the protein products of the RAD51 gene, including the pairing of compatible chromosomes--the structures that contain the cell's genes--during the ...

The cryoEM structure of a RAD51 displacement loop reveals the molecular mechanism of the strand-exchange reaction at the centre of eukaryotic homologous recombination.

An open question in meiosis is whether the Rad51 recombination protein functions solely in meiotic recombination or whether it is also involved in the chromosome homology search. To address this ...

XRCC2 may interact with Rad51 through its interaction with Rad51D, since Rad51D interacts with a postulated Rad51C/B heterodimer. Although their role in promoting recombination is unknown, it has been ...

The one that CNIO researchers have now discovered involves the RAD51 protein. Its mission, in this context, is to prevent DNA fragments that have already been copied once from being copied again.

By visualizing BRCA2 function at a single molecule level, Kowalczykowski’s team discovered that it acts as a molecular chaperone, delivering another protein, RAD51, to single-stranded DNA. It ensures ...

RAD51 immunofluorescence showed that 21% of evaluable samples had a RAD51-low score, indicating HRR deficiency, and a high sensitivity and specificity for identifying tumors with BRCA1/2 alterations.

Pellegrini continues, "One interesting observation we made is that at one end of the D-loop structure, the L2 loops of RAD51 cause a large alteration to open up the donor DNA, but at the other end ...

A new research paper was published in Oncotarget's Volume 15 on October 1, 2024, entitled, "Next-generation cell-penetrating antibodies for tumor targeting and RAD51 inhibition." ...

The team's work reveals specific functions of the protein products of the RAD51 gene, including the pairing of compatible chromosomes--the structures that contain the cell's genes--during the ...