RPA has a higher affinity for ssDNA than Rad51, and it therefore can inhibit recombination by blocking Rad51's access to the single strand needed for invasion. In yeast, however, binding of Rad51 ...

Currently, we are focusing on two related areas: (1) the mechanism of DNA homology search and strand transfer promoted by the human recombinational proteins, Rad51 and Rad54. (2) The purification and ...

This reaction is carried out by the RecA/Rad51 family of ATPases. In repair, the DSB is resected to produce ssDNA, which is then coated by RecA/Rad51 to produce a presynaptic nucleoprotein filament, ...