Evolution- and structure-guided mutagenesis allows elucidation of the solution NMR structure of the N-terminal domain of APOBEC3G. Mapping of HIV-1 Vif binding to the APOBEC3G NTD reveals an ...

Continuing work includes identifying substances that bind to and inhibit Vif in the cell. But for now, the function of CEM15, and how Vif suppresses this function, remain to be determined.