Two simple molecules can react to form most of the intermediates in an analog of the modern-day Krebs cycle, without the need for enzymes or metals, according to a new study (Nat. Chem. 2020, DOI ...

CPI-613 (devimistat), a novel systemic therapeutic that targets the TCA cycle by inhibiting pyruvate dehydrogenase (PDH) and ketoglutarate dehydrogenase (KGDH), was used to treat HNSCC cells. MOC2 ...

The Krebs cycle in the mitochondria of cells is used to supply both energy and building materials for cell growth. Two mitochondrial enzymes -- pyruvate carboxylase (PC) and glutaminase replenish ...